Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC007
Sex MALE
Dominant hand LEFT
Test date and time 2022-02-18 14:59
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment Madopar a 250mg 3x1/4 Madopar HBS jedna uvece (terapijasada uvedena)

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 15 individuals with a value less than 0.56 were subsequently diagnosed with PD. That is, 35.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.56 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 36, 'TN': 27, 'TP': 6, 'FP': 3}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 39, 'TN': 28, 'TP': 3, 'FP': 2}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 15, 'TP': 19, 'FP': 15}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 29, 'TN': 19, 'TP': 13, 'FP': 11}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.084
timePerCircleCoV 0.260445
timePerCircleSlope -0.0472913
meanError 2.06413
tremorFreq 5.66406
tremorRelPower 34.4132
tremorGyroAmpMean 0.026907
tremorGyroAmpSlope 0.00610765
tremorGyroAmpCoV 0.421308
tremorCoordAmpMean 0.104676
tremorCoordAmpSlope 0.0100895
tremorCoordAmpCoV 0.650542
tremorAccAmpMean 0.0999005
tremorAccAmpSlope 0.00258747
tremorAccAmpCoV 0.233285
tremorPcRelVar 0.588027
tremorPcX -0.00433883
tremorPcY -0.999991

Circle Segment 1

Duration 10.28 s, Accuracy Estimate 2.877 (lower is better)

Circle Segment 2

Duration 12.68 s, Accuracy Estimate 1.627 (lower is better)

Circle Segment 3

Duration 6.16 s, Accuracy Estimate 1.885 (lower is better)

Circle Segment 4

Duration 8.6 s, Accuracy Estimate 1.711 (lower is better)

Circle Segment 5

Duration 7.28 s, Accuracy Estimate 2.059 (lower is better)

Circle Segment 6

Duration 6.84 s, Accuracy Estimate 2.148 (lower is better)

Circle Segment 7

Duration 6.68 s, Accuracy Estimate 1.841 (lower is better)

Circle Segment 8

Duration 6.84 s, Accuracy Estimate 1.772 (lower is better)

Circle Segment 9

Duration 9.16 s, Accuracy Estimate 1.949 (lower is better)

Circle Segment 10

Duration 6.32 s, Accuracy Estimate 2.773 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 11.744
timePerSpiralCoV 0.215917
timePerSpiralSlope -0.0542482
meanError 2.6866
tremorFreq 5.95703
tremorRelPower 31.5255
tremorGyroAmpMean 0.0414931
tremorGyroAmpSlope 0.00552121
tremorGyroAmpCoV 0.339507
tremorCoordAmpMean 0.284146
tremorCoordAmpSlope 0.00705206
tremorCoordAmpCoV 0.822798
tremorAccAmpMean 0.105055
tremorAccAmpSlope 0.00395954
tremorAccAmpCoV 0.395544
tremorPcRelVar 0.622269
tremorPcX -0.999423
tremorPcY -0.0339545

Spiral Segment 1

Duration 16.2 s, Accuracy Estimate 1.994 (lower is better)

Spiral Segment 2

Duration 13.2 s, Accuracy Estimate 2.084 (lower is better)

Spiral Segment 3

Duration 13.64 s, Accuracy Estimate 2.462 (lower is better)

Spiral Segment 4

Duration 13.04 s, Accuracy Estimate 2.467 (lower is better)

Spiral Segment 5

Duration 12.6 s, Accuracy Estimate 2.392 (lower is better)

Spiral Segment 6

Duration 9.64 s, Accuracy Estimate 2.593 (lower is better)

Spiral Segment 7

Duration 9.52 s, Accuracy Estimate 2.732 (lower is better)

Spiral Segment 8

Duration 8.64 s, Accuracy Estimate 3.003 (lower is better)

Spiral Segment 9

Duration 8.52 s, Accuracy Estimate 3.29 (lower is better)

Spiral Segment 10

Duration 12.44 s, Accuracy Estimate 3.85 (lower is better)

Elel

eDurationMean 0.458902
eDurationStd 0.103534
eDurationStdnorm 0.225613
eDurationMedian 0.445
eDurationQuartdelta 0.13125
eDurationQuartdeltanorm 0.294944
eDurationKurt 3.52172
eDurationTrenddiff -0.095
eDurationTrendratio 0.804124
eWidthMean 9.48161
eWidthStd 3.49199
eWidthStdnorm 0.368291
eWidthMedian 9.26664
eWidthQuartdelta 3.63588
eWidthQuartdeltanorm 0.392363
eWidthKurt 3.17125
eWidthTrenddiff -0.45432
eWidthTrendratio 0.951084
eHeightMean 16.1181
eHeightStd 4.0559
eHeightStdnorm 0.251636
eHeightMedian 16.965
eHeightQuartdelta 5.40638
eHeightQuartdeltanorm 0.318678
eHeightKurt 4.1597
eHeightTrenddiff -1.45037
eHeightTrendratio 0.915562
eAspectMean 0.590671
eAspectStd 0.189538
eAspectStdnorm 0.320886
eAspectMedian 0.519155
eAspectQuartdelta 0.244072
eAspectQuartdeltanorm 0.470133
eAspectKurt 2.38787
eAspectTrenddiff 0.0779141
eAspectTrendratio 1.1621
eSlantMean 0.176246
eSlantStd 0.279975
eSlantStdnorm 1.58854
eSlantMedian 0.179625
eSlantQuartdelta 0.251586
eSlantQuartdeltanorm 1.40062
eSlantKurt 5.40936
eSlantTrenddiff 0.0336581
eRtopMean 0.845983
eRtopStd 0.103411
eRtopStdnorm 0.122238
eRtopMedian 0.846157
eRtopQuartdelta 0.128985
eRtopQuartdeltanorm 0.152437
eRtopKurt 4.82486
eRtopTrenddiff -0.0184206
eRbotMean 0.564234
eRbotStd 0.420054
eRbotStdnorm 0.744467
eRbotMedian 0.464209
eRbotQuartdelta 0.405511
eRbotQuartdeltanorm 0.873553
eRbotKurt 6.29913
eRbotTrenddiff -0.0690377
eRrightMean 0.873837
eRrightStd 0.0963639
eRrightStdnorm 0.110277
eRrightMedian 0.888873
eRrightQuartdelta 0.132985
eRrightQuartdeltanorm 0.14961
eRrightKurt 4.66772
eRrightTrenddiff -0.0308033
eRleftMean 0.294291
eRleftStd 0.145977
eRleftStdnorm 0.496029
eRleftMedian 0.256714
eRleftQuartdelta 0.160225
eRleftQuartdeltanorm 0.624137
eRleftKurt 3.66022
eRleftTrenddiff -0.0228702
lDurationMean 0.519432
lDurationStd 0.152629
lDurationStdnorm 0.293838
lDurationMedian 0.485
lDurationQuartdelta 0.16
lDurationQuartdeltanorm 0.329897
lDurationKurt 5.5755
lDurationTrenddiff -0.06
lDurationTrendratio 0.885714
lWidthMean 15.4991
lWidthStd 3.37833
lWidthStdnorm 0.217969
lWidthMedian 15.4635
lWidthQuartdelta 4.49929
lWidthQuartdeltanorm 0.290962
lWidthKurt 2.85978
lWidthTrenddiff 0.752333
lWidthTrendratio 1.05096
lHeightMean 34.4498
lHeightStd 5.64653
lHeightStdnorm 0.163906
lHeightMedian 34.9237
lHeightQuartdelta 6.36649
lHeightQuartdeltanorm 0.182297
lHeightKurt 4.55416
lHeightTrenddiff -3.87248
lHeightTrendratio 0.896362
lAspectMean 0.456572
lAspectStd 0.114393
lAspectStdnorm 0.250547
lAspectMedian 0.439627
lAspectQuartdelta 0.0988368
lAspectQuartdeltanorm 0.22482
lAspectKurt 9.95446
lAspectTrenddiff 0.0484622
lAspectTrendratio 1.11625
lSlantMean 0.27798
lSlantStd 0.163236
lSlantStdnorm 0.587223
lSlantMedian 0.282458
lSlantQuartdelta 0.145683
lSlantQuartdeltanorm 0.515768
lSlantKurt 11.3332
lSlantTrenddiff 0.00389269
lRtopMean 0.935801
lRtopStd 0.0608009
lRtopStdnorm 0.064972
lRtopMedian 0.949591
lRtopQuartdelta 0.0652843
lRtopQuartdeltanorm 0.0687499
lRtopKurt 6.83341
lRtopTrenddiff -0.019649
lRbotMean 0.337591
lRbotStd 0.366641
lRbotStdnorm 1.08605
lRbotMedian 0.276535
lRbotQuartdelta 0.223848
lRbotQuartdeltanorm 0.809474
lRbotKurt 24.4296
lRbotTrenddiff 0.0887764
lRrightMean 0.946961
lRrightStd 0.047325
lRrightStdnorm 0.0499756
lRrightMedian 0.957751
lRrightQuartdelta 0.0626664
lRrightQuartdeltanorm 0.0654308
lRrightKurt 3.54776
lRrightTrenddiff 0.00481684
lRleftMean 0.181328
lRleftStd 0.11845
lRleftStdnorm 0.653234
lRleftMedian 0.170626
lRleftQuartdelta 0.112973
lRleftQuartdeltanorm 0.66211
lRleftKurt 6.40977
lRleftTrenddiff 0.0525035

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.49583
sumTouchScores 12.8916
meanMovementTime 0.7314
numTouches 26
undershootPercentage 0
overshootPercentage 61.5385

FITTS Long Modified

meanTouchScore 0.622123
sumTouchScores 8.08759
meanMovementTime 1.10375
numTouches 13
undershootPercentage 0
overshootPercentage 69.2308

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 13.12
timePerZigzagCoV 0.168264
timePerZigzagSlope 0.054878
meanError 3.94983
tremorFreq 5.66406
tremorRelPower 37.4489
tremorGyroAmpMean 0.0815275
tremorGyroAmpSlope -0.00934574
tremorGyroAmpCoV 0.495952
tremorCoordAmpMean 0.413968
tremorCoordAmpSlope -0.000914579
tremorCoordAmpCoV 0.765414
tremorAccAmpMean 0.16971
tremorAccAmpSlope -0.0103229
tremorAccAmpCoV 0.30187
tremorPcRelVar 0.828595
tremorPcX -0.192464
tremorPcY -0.981304

ZigZag Segment 1

Duration 9.84 s, Accuracy Estimate 3.991 (lower is better)

ZigZag Segment 2

Duration 12.96 s, Accuracy Estimate 3.701 (lower is better)

ZigZag Segment 3

Duration 16.0 s, Accuracy Estimate 3.951 (lower is better)

ZigZag Segment 4

Duration 13.76 s, Accuracy Estimate 4.417 (lower is better)

ZigZag Segment 5

Duration 13.04 s, Accuracy Estimate 3.689 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 10.576
timePerZigzagCoV 0.321345
timePerZigzagSlope -0.19289
zigzagHeightMean 66.2502
zigzagHeightCoV 0.0888684
zigzagHeightSlope 0.0533168
meanError 0.062428
tremorFreq 5.56641
tremorRelPower 26.959
tremorGyroAmpMean 0.0605397
tremorGyroAmpSlope -0.000513337
tremorGyroAmpCoV 0.423042
tremorCoordAmpMean 0.401535
tremorCoordAmpSlope -0.0136118
tremorCoordAmpCoV 0.879314
tremorAccAmpMean 0.116373
tremorAccAmpSlope -0.0011142
tremorAccAmpCoV 0.322417
tremorPcRelVar 0.883613
tremorPcX -0.254937
tremorPcY -0.966958

ZigZag Offset Segment 1

Duration 15.6 s, Accuracy Estimate 0.096 (lower is better)

ZigZag Offset Segment 2

Duration 12.48 s, Accuracy Estimate 0.075 (lower is better)

ZigZag Offset Segment 3

Duration 9.2 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 4

Duration 7.92 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 5

Duration 7.68 s, Accuracy Estimate 0.056 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.71}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.56}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.0007958389653839326}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8868769767208671}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44192353540889495}